thle 2 (ATCC)
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thle 2
Thle 2, supplied by ATCC, used in various techniques. Bioz Stars score: 98/100, based on 650 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/thle+2/THLE-2/pmc13214269-74-0-2
Average 98 stars, based on 650 article reviews
Thle 2, supplied by ATCC, used in various techniques. Bioz Stars score: 98/100, based on 650 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/thle+2/THLE-2/pmc13214269-74-0-2
Average 98 stars, based on 650 article reviews
thle 2 - by Bioz Stars,
2026-10
98/100 stars
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In Vitro:Article Title: Development of Type II Glucose Transporter Inhibitors: Phloretin as a GLUT-2 Screening Template from In Silico Modeling to In Vitro Assessment Article Snippet: .. HepG2 (human HCC; ATCC HB-8065; ATCC, Manassas, VA, USA) and Article Title: KCMF1 promotes MASLD progression via K48-linked ubiquitination and degradation of AMPKα. Article Snippet: Background/Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) lacks effective pharmacotherapy.. Although AMP-activated protein kinase (AMPK) is a central metabolic regulator with hepatoprotective effects, the upstream mechanisms governing its degradation in MASLD remain poorly defined.. Here, we identify potassium channel modulatory factor 1 (KCMF1) as a previously unrecognized E3 ubiquitin ligase targeting AMPKα and investigate its role in MASLD pathogenesis. Derivative Assay:Article Title: Anti-variable MUC1* antibodies and uses thereof Article Snippet: .. TABLE 1 Normal Cell Lines and Primary Cells ATCC Cell Line Designation Tissue Origin Hep.G2 Liver THLE-3 CRL-11233 Liver The Infection:Article Title: Anti-variable MUC1* antibodies and uses thereof Article Snippet: .. TABLE 1 Normal Cell Lines and Primary Cells ATCC Cell Line Designation Tissue Origin Hep.G2 Liver THLE-3 CRL-11233 Liver The Cell Culture:Article Title: KCMF1 promotes MASLD progression via K48-linked ubiquitination and degradation of AMPKα. Article Snippet: Background/Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) lacks effective pharmacotherapy.. Although AMP-activated protein kinase (AMPK) is a central metabolic regulator with hepatoprotective effects, the upstream mechanisms governing its degradation in MASLD remain poorly defined.. Here, we identify potassium channel modulatory factor 1 (KCMF1) as a previously unrecognized E3 ubiquitin ligase targeting AMPKα and investigate its role in MASLD pathogenesis. Transfection:Article Title: KCMF1 promotes MASLD progression via K48-linked ubiquitination and degradation of AMPKα. Article Snippet: Background/Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) lacks effective pharmacotherapy.. Although AMP-activated protein kinase (AMPK) is a central metabolic regulator with hepatoprotective effects, the upstream mechanisms governing its degradation in MASLD remain poorly defined.. Here, we identify potassium channel modulatory factor 1 (KCMF1) as a previously unrecognized E3 ubiquitin ligase targeting AMPKα and investigate its role in MASLD pathogenesis. other:Article Title: Phospho-JNK agonists show promising effects for the treatment of hepatocellular carcinoma Article Snippet: Vaccines:Article Title: Phytochemical-mediated green synthesis of selenium nanoparticles using Catharanthus roseus and their physicochemical characterization, biological evaluation, and molecular docking analysis Article Snippet: .. |
![Effect of Phe on human hepatocytes and adipocytes. (A) Real‐time extracellular acidification rate (ECAR), (B) glycolytic parameters (basal [BG] and compensatory [CG] glycolysis and 2‐deoxy‐D‐glucose [2‐DG] post acidification), (C and E) fibroblast growth factor 21 (FGF21; gene name FGF21 ) mRNA levels and (D and F) FGF21 protein levels in the supernatant of transformed human liver epithelial‐2 <t>(THLE‐2)</t> human hepatocytes (A–D) or Simpson–Golabi–Behmel Syndrome (SGBS) human adipocytes (E and F) after phenylalanine (Phe) treatments at different dosages (2.5, 5, and 10 mM) and times (6 and 12 h). Glyceraldehyde‐3‐phosphate dehydrogenase (GAPDH; gene name GAPDH ) was used as housekeeping gene to serve as an internal control in the mRNA analyses. Data are expressed as mean ± SEM. Statistical significance was determined by one‐way ANOVA followed of Bonferroni test or Kruskal–Wallis followed of Dunn's test; normality was assayed with Shapiro–Wilk test. Alpha level was set at 0.05. * p < 0.05, ** p < 0.01, *** p < 0.001, and **** p < 0.0001. All statistical tests were two‐sided.](https://pub-med-central-images-cdn.bioz.com/pub_med_central_ids_ending_with_3790/pmc13263790/pmc13263790__MCO2-7-e70820-g003.jpg)